TBM Longitudinal Jacobians and Analysis


 

Written by Owen Phillips. Email Dr. Katherine Narr if you have any questions. For more information, see the protocols page.

Dicom to analyze.img
TBM Jacobian

Tensor based morphometry requires all your study subjects to be registered together so that an atlas can be generated. This protocol is set up to allow a longitudinal analysis. It will generate one jacobian image for each subject who was scanned at two time points. Right click the following link to download: TBM_Longitudinal_MDT_v9

Inputs:

  1. Raw Data Time 1
  2. 1st subject - this is just used to set the histograms for the rest of the subjects.
  3. Raw Data Time 2
  4. *note, this pipeline includes extra modules like Bias Field Corrector, this can be cut out of the pipeline if it is not needed.

Outputs:

  1. Longitudinal Jacobians
  2. 4-step MDT
  3. KL_MI_deform 2

Analysis: You can download the pipeline for TBM Longitudinal Analysis by right clicking: One_Sample_t-test

Inputs:

  1. Input Design Matrix: See http://wiki.stat.ucla.edu/socr/index.php/SOCR_EduMaterials_AnalysesCommandLineVolumeMultipleRegression for instructions on how to make this.
  2. Mask

Outputs:

  1. P-value output volume
  2. T-statistic
  3. FDR corrected P-value